Mike is a Principal Scientist and the Science Area Leader of NPL’s Biometrology Group, where he leads a multidisciplinary team of scientists working to address a range of measurement challenges in the health and life sciences. A physicist by background, his own research focuses on high-resolution microscopy techniques for visualisation and quantitative analysis of biological systems and processes.
Mike also leads a computational optical microscopy group in the Department of Computer Science at University College London. He is a Visiting Professor at the University of Strathclyde, a Chartered Physicist and a member of BSI CPW/172 (optics and photonics).
Biography
Mike joined NPL in 2001 after completing an MSci degree in Physics at Imperial College London. His early work concerned the development of methods and instrumentation for measuring the optical properties of materials (scattering and fluorescence) and light sources (spectroradiometry). Mike continued his research in applied optics by working on metrological techniques for adaptive optics and high-resolution imaging. During this time he completed his PhD, titled 'Overcoming resolution limits in fluorescence microscopy with adaptive optics and structured illumination'. Since joining NPL's Biometrology group in 2010 his primary research focus has been to develop fluorescence microscopy techniques for spatio-temporal analysis of peptides and proteins, cells and multicellular models.
Research interests
- Visualisation and quantitative imaging of biological systems
- Intracellular delivery and cell-ECM interactions.
- Super-resolution structured illumination microscopy (SIM), light sheet microscopy, computational microscopy (light field and ptychographic techniques).
- Correlative and multimodal imaging.
- Image processing and analysis
- Microscope calibration and standardisation
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