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Dimitrios Tsikritsis

Dimitrios Tsikritsis

Higher scientist

Dimitrios Tsikritsis is a Higher Scientist in the Surface Technology Group. His research interests focus on Raman spectroscopy and nonlinear imaging techniques including coherent anti-Stokes Raman scattering (CARS), stimulated Raman scattering (SRS) microscopy, second harmonic generation (SHG) and two photon excitation fluorescence (TPEF). Dimitrios applies these methods to characterise formulated products and their performance, including imaging drug disposition in cells and tissue as well as the characterisation of products in the food and beverage industry.

Dimitrios graduated with MEng in 2009 from Sussex University in Electrical and Electronics Engineering, and then undertook his MSc in Bioelectronics at the University of Edinburgh where he remained for his PhD in the application of vibrational spectroscopy and nonlinear imaging in colorectal cancer diagnostics. Dimitrios joined NPL in 2017, he is a member of the Royal Society of Chemistry, Royal Microscopy Society and a member of the Institution of Engineering and Technology.

Areas of interest:

  • Drug uptake characterisation with coherent Raman scattering microscopy and spontaneous Raman spectroscopy
  • Multiphoton and correlative imaging on live cells and tissue
  • Molecular digital pathology
  • Standardisation of Raman based technologies
  • Chemometrics for Raman spectroscopy

Selected publication list:

  • Taylor, AJ, Tsikritsis, D, Dexter, A, Burton, A, Bunch, J, Belsey, NA. Classification of tablet formulations by desorption electrospray ionisation mass spectrometry and transmission Raman spectroscopy. Journal of Chemometrics. 2022; 36(6):e3412. doi:10.1002/cem.3412
     
  • Tsikritsis, D., Legge, E. J., & Belsey, N. A. (2022). Practical considerations for quantitative and reproducible measurements with stimulated Raman scattering microscopy. Analyst. https://doi.org/10.1039/D2AN00817C
  • Dexter, A.; Tsikritsis, D.; Belsey, N.A.; Thomas, S.A.; Venton, J.; Bunch, J.; Romanchikova, M. Next Generation Digital Pathology: Emerging Trends and Measurement Challenges for Molecular Pathology. J. Mol. Pathol. 2022, 3, 168-181. https://doi.org/10.3390/jmp3030014
     
  • Tsikritsis, Dimitrios, et al. "Label-free identification and characterization of living human primary and secondary tumour cells." Analyst 140.15 (2015): 5162-5168.

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