Christian Bortolini joined the Surface Technology Group at NPL in November 2023 as a Higher Scientist. His work focuses on biological applications of Atomic Force Microscopy (AFM) with a particular interest in exploring the nano mechanics of biomaterials.
Christian obtained his PhDs from Aarhus University (Denmark) in Nanoscience, and from the University of the Chinese Academy of Sciences (P.R. China) in Physical Chemistry, working on peptide self assembly.
He was awarded an individual postdoctoral fellowship from the Lundbeck Foundation to carry out independent work in amyloid biophysics at Aarhus and Cambridge Universities. He then worked as a postdoc on cancer research at Imperial College London, and on the complement membrane attack complex in the context of antimicrobial resistance at University College London and King’s College London.
Selected Publications
C.Bortolini*, G.Benn*, D.M.Roberts, A.L.B.Pyne, S.Holden, B.W.Hoogenboom. Complement-mediated killing of bacteria by mechanical destabilization of the cell envelope. bioRxiv (2023). * These authors contributed equally
G.Benn, I.V.Mikheyeva, P.G.Inns, J.C.Forster, N.Ojkic, C.Bortolini, M.G.Ryadnov, C.Kleanthous, T.J.Silhavy, B.W.Hoogenboom. Phase separation in the outer membrane of Escherichia coli. PNAS, 118(44) (2021).
C.Bortolini, T.Kartanas, D.Copic, I.Condado Morales, Y.Zhang, P.K.Challa, Q.A.E.Peter, T.Javorfi, R.Hussain, M.Dong, G.Siligardi, T.P.J.Knowles, J.Charmet. Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism. Lab on a Chip, 19(1):p.50-58 (2019).
C.Bortolini, L.H.Klausen, S.Hoffmann, N.C.Jones, D.Saadeh, Z.Wang, T.P.J.Knowles, M.Dong. Rapid growth of acetylated Aβ16−20 into macroscopic crystals. ACS Nano, 12(6):p.5408- 5416 (2018).
C.Bortolini, N.C.Jones, S.Hoffmann, C.Wang, F.Besenbacher, M.Dong. Mechanical properties of amyloid-like fibrils defined by secondary structures. Nanoscale, 7(17):p.7745-7752 (2015).
Email Christian Bortolini
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